Journal: Frontiers in cellular neuroscience

Article Title: Alterations of Electrophysiological Properties and Ion Channel Expression in Prefrontal Cortex of a Mouse Model of Schizophrenia.

doi: 10.3389/fncel.2019.00554

Figure Lengend Snippet: FIGURE 1 | MIA-SI animals develop schizophrenia-like behaviors, including deficits in jumping behavior, social novelty preference, working memory and sensorimotor gating function. (A) Overview of the experimental design. OFT, open field test; SIT, social interaction test; RAM, radial arm maze; PPI, prepulse inhibition. (B) Total distance traveled was not changed by MIA-SI in OFT. (C) Increased jumping time was observed in MIA-SI animals in OFT. (D) Top, time spent in the non-social chamber (inanimate) versus the social chamber (stranger 1) during the sociability session in SIT, indicating MIA-SI didn’t affect sociability. Bottom, time spent in the chamber with familiar mouse (stranger 1) versus that with novel mouse (stranger 2) during social novelty preference session in SIT, suggesting MIA-SI caused deficit in social novelty preference. (E) Working memory errors committed across five test days in RAM test. (F) Average daily working memory errors over five test days was increased in MIA-SI animals. (G) Time to complete the trial across five test days in RAM test. (H) PPI deficits following poly I:C challenge and isolation rearing. ∗p < 0.05; ∗∗∗p < 0.001. Control, n = 7; MIA-SI, n = 8.

Article Snippet: Prepulse Inhibition Prepulse inhibition (PPI) was measured using an acoustic startle reflex system (Med Associates Inc., United States) as described previously (Hadar et al., 2018).

Techniques: Inhibition, Isolation, Control

Journal: Psychopharmacology

Article Title: Fronto-temporal-mesolimbic gene expression and heritable differences in amphetamine-disrupted sensorimotor gating in rats

doi: 10.1007/s00213-012-2758-1

Figure Lengend Snippet: Startle phenotypes of SD vs. LE rats in the present study. Bottom: percent PPI over prepulse intervals of 10–120 ms in SD (left) and LE (right) rats after administration of saline vehicle (open circles) or AMPH (4.5 mg/kg, sc; filled circles). Oval highlights PPI-enhancing effects of AMPH with 30-ms prepulse intervals in LE (#), but not SD rats. Rectangle highlights greater PPI-disruptive effects of AMPH with 120-ms prepulse intervals in SD vs. LE rats (*). Inset shows startle magnitude on pulse-alone trials during PPI testing, with significant startle-potentiating effects detected only in male LE rats (*)

Article Snippet: Rationale Differences in sensitivity to the prepulse inhibition (PPI)-disruptive effects of D2-family agonists in Sprague–Dawley (SD) vs. Long Evans (LE) rats are heritable, reflect differential activation of DA signaling in the nucleus accumbens (NAC), and are associated with differences in expression of specific NAC genes.

Techniques: Saline

Journal: Neuropsychopharmacology

Article Title: Modern Clinical Research on LSD

doi: 10.1038/npp.2017.86

Figure Lengend Snippet: Modern Clinical Placebo-Controlled LSD Studies

Article Snippet: Schmid et al , 2015 , Acoustic startle , Disruption of prepulse inhibition (PPI).

Techniques: Clinical Proteomics, Disruption, Inhibition, Drug discovery, Concentration Assay, Activation Assay, Functional Assay, Activity Assay

Journal: Frontiers in Behavioral Neuroscience

Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

doi: 10.3389/fnbeh.2023.1325051

Figure Lengend Snippet: Timeline of the behavioral tests. Each animal completed all behavioral tests, except for Phenotyper that was performed only for a subset of animals: Phenotyper—myoclonus detection; CatWalk—walking pattern (coordination), speed of walk; Startle—startle response, prepulse inhibition; Beam walk—coordination; Elevated plus maze—hyperactivity, speed of walk; Grip strength—strength.

Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

Techniques: Inhibition

Journal: Frontiers in Behavioral Neuroscience

Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

doi: 10.3389/fnbeh.2023.1325051

Figure Lengend Snippet: Cstb −/− mice show progressive myoclonus and altered startle response. (A) Myoclonic events were detected in PhenoTyper cages for a period of 3 h at 1.5, 3, and 6 months of age. (B) Progression of myoclonic events from 1.5 to 6 months of age in individual animals (see for separate graphs of Cstb −/− mice). (C) Cstb −/− mice show reduced startle response to 100 dB noise at 3, 5, and 6 months of age compared to the wild type ( wt ) mice. (D–F) Prepulse inhibition (PPI) at 69, 73, and 77 dB prepulse intensities is decreased in Cstb −/− mice at the age of 3 (D) , 5 (E) , and 6 (F) months. Data are presented as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001, N = 12 for (A,B) , N = 15–16 for (C–F) .

Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

Techniques: Inhibition

Journal: Frontiers in Behavioral Neuroscience

Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

doi: 10.3389/fnbeh.2023.1325051

Figure Lengend Snippet: Comparison of the symptoms in EPM1 patients and in Cstb −/− mice.

Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

Techniques: Comparison, Inhibition